Quick notes - Oxyhaemoglobin affinity Oxygen-haemoglobin affinity Oxyhaemoglobin affinity decreases (ie. shifts to the RIGHT) in situations where greater O2 is required– High temperature– Low oxygen– High pCO2– Acidosis– Raised 2,3-DPG (in chronic hypoxia, eg. altitude, chronic lung disease) CADET : CO2, Acidosis, 2,3-DPG, Exercise, Temperature